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[[Image:4gtf.jpg|left|200px]]


{{STRUCTURE_4gtf| PDB=4gtf | SCENE= }}  
==T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate==
<StructureSection load='4gtf' size='340' side='right'caption='[[4gtf]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4gtf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GTF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MEF:N-({4-[(6AR)-3-AMINO-1-OXO-1,2,5,6,6A,7-HEXAHYDROIMIDAZO[1,5-F]PTERIDIN-8(9H)-YL]PHENYL}CARBONYL)-L-GLUTAMIC+ACID'>MEF</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gtf OCA], [https://pdbe.org/4gtf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gtf RCSB], [https://www.ebi.ac.uk/pdbsum/4gtf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gtf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THYX_THEMA THYX_THEMA] Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate.


===T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate===
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
{{ABSTRACT_PUBMED_23019356}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[4gtf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GTF OCA].
[[Category: Thermotoga maritima MSB8]]
[[Category: Thermotoga maritima msb8]]
[[Category: Kohen A]]
[[Category: Kohen, A.]]
[[Category: Lesley SA]]
[[Category: Lesley, S A.]]
[[Category: Mathews II]]
[[Category: Mathews, I I.]]
[[Category: 10-methylenetetrahydrofolate]]
[[Category: Dump]]
[[Category: Fad]]
[[Category: Flavin-dependent thymidylate synthase]]
[[Category: H53a mutant]]
[[Category: Tm0449]]
[[Category: Transferase]]

Latest revision as of 15:56, 14 March 2024

T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate

4gtf, resolution 1.77Å

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