3vup: Difference between revisions

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[[Image:3vup.jpg|left|200px]]


{{STRUCTURE_3vup| PDB=3vup | SCENE= }}
==Beta-1,4-mannanase from the common sea hare Aplysia kurodai==
<StructureSection load='3vup' size='340' side='right'caption='[[3vup]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3vup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_kurodai Aplysia kurodai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VUP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vup OCA], [https://pdbe.org/3vup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vup RCSB], [https://www.ebi.ac.uk/pdbsum/3vup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vup ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E5RSM0_APLKU E5RSM0_APLKU]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
beta-1,4-Mannanase (EC 3.2.1.78) catalyzes the hydrolysis of beta-1,4-glycosidic bonds within mannan, a major constituent group of the hemicelluloses. Bivalves and gastropods possess beta-1,4-mannanase and may degrade mannan in seaweed and/or phytoplankton to obtain carbon and energy using the secreted enzymes in their digestive systems. In the present study, the crystal structure of AkMan, a gastropod beta-1,4-mannanase prepared from the common sea hare Aplysia kurodai, was determined at 1.05 A resolution. This is the first report of the three-dimensional structure of a gastropod beta-1,4-mannanase. The structure was compared with bivalve beta-1,4-mannanase and the roles of residues in the catalytic cleft were investigated. No obvious binding residue was found in subsite +1 and the substrate-binding site was exposed to the molecular surface, which may account for the enzymatic properties of mannanases that can digest complex substrates such as glucomannan and branched mannan.


===Beta-1,4-mannanase from the common sea hare Aplysia kurodai===
Structure of beta-1,4-mannanase from the common sea hare Aplysia kurodai at 1.05 A resolution.,Mizutani K, Tsuchiya S, Toyoda M, Nanbu Y, Tominaga K, Yuasa K, Takahashi N, Tsuji A, Mikami B Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1164-8., doi: 10.1107/S1744309112037074. Epub 2012 Sep 25. PMID:23027740<ref>PMID:23027740</ref>


{{ABSTRACT_PUBMED_23027740}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3vup" style="background-color:#fffaf0;"></div>
[[3vup]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aplysia_kurodai Aplysia kurodai]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VUP OCA].
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aplysia kurodai]]
[[Category: Aplysia kurodai]]
[[Category: Mikami, B.]]
[[Category: Large Structures]]
[[Category: Mizutani, K.]]
[[Category: Mikami B]]
[[Category: Nanbu, Y.]]
[[Category: Mizutani K]]
[[Category: Takahashi, N.]]
[[Category: Nanbu Y]]
[[Category: Tominaga, K.]]
[[Category: Takahashi N]]
[[Category: Toyoda, M.]]
[[Category: Tominaga K]]
[[Category: Tsuchiya, S.]]
[[Category: Toyoda M]]
[[Category: Tsuji, A.]]
[[Category: Tsuchiya S]]
[[Category: Yuasa, K.]]
[[Category: Tsuji A]]
[[Category: 4-mannanase]]
[[Category: Yuasa K]]
[[Category: Beta-1]]
[[Category: Digestive fluid]]
[[Category: Hydrolase]]
[[Category: Mannan]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/3vup"