3sqy: Difference between revisions

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[[Image:3sqy.png|left|200px]]


{{STRUCTURE_3sqy|  PDB=3sqy  |  SCENE=  }}
==S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines==
 
<StructureSection load='3sqy' size='340' side='right'caption='[[3sqy]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
===S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3sqy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SQY FirstGlance]. <br>
{{ABSTRACT_PUBMED_21831637}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q11:7-(2-METHOXYPHENYL)QUINAZOLINE-2,4-DIAMINE'>Q11</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sqy OCA], [https://pdbe.org/3sqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sqy RCSB], [https://www.ebi.ac.uk/pdbsum/3sqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sqy ProSAT]</span></td></tr>
[[3sqy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQY OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


==See Also==
==See Also==
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021831637</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Dihydrofolate reductase]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Hilgers, M.]]
[[Category: Hilgers M]]
[[Category: Dhfr]]
[[Category: Dihydrofolate reductase]]
[[Category: Drug design]]
[[Category: Enzyme inhibitor]]
[[Category: Folate]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Latest revision as of 09:54, 1 March 2024

S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines

3sqy, resolution 1.50Å

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