3kam: Difference between revisions

Latest revision as of 06:23, 27 November 2024

Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation

Structural highlights

3kam is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.59Å
Ligands:	CL, CMO, NA, RE
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSC_CHICK Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The reaction of Re(CO)(3)(H(2)O)(3)(+) with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.

Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+).,Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
↑ Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS. Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+). Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250 doi:10.1039/b923688k

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021

[2] Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS. Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+). Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250 doi:10.1039/b923688k

[1]

[2]

@@ Line 1: / Line 1: @@
-[[Image:3kam.png|left|200px]]
-{{STRUCTURE_3kam|  PDB=3kam  |  SCENE=  }}
+==Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation==
+<StructureSection load='3kam' size='340' side='right'caption='[[3kam]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3kam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KAM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RE:RHENIUM'>RE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kam OCA], [https://pdbe.org/3kam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kam RCSB], [https://www.ebi.ac.uk/pdbsum/3kam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kam ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/3kam_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kam ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The reaction of Re(CO)(3)(H(2)O)(3)(+) with hen egg lysozyme in aqueous solution results in a single covalent adduct; single crystal X-ray diffraction shows that the rhenium tricarbonyl cation binds to His15 in two significantly populated rotamer conformations.
-===Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation===
+Specific derivatization of lysozyme in aqueous solution with Re(CO)3(H2O)3(+).,Binkley SL, Ziegler CJ, Herrick RS, Rowlett RS Chem Commun (Camb). 2010 Feb 28;46(8):1203-5. Epub 2010 Jan 9. PMID:20449250<ref>PMID:20449250</ref>
-{{ABSTRACT_PUBMED_20449250}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3kam" style="background-color:#fffaf0;"></div>
-[[3kam]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAM OCA].
 ==See Also==
-*[[Hen Egg-White (HEW) Lysozyme|Hen Egg-White (HEW) Lysozyme]]
+*[[Lysozyme 3D structures|Lysozyme 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:020449250</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Gallus gallus]]
-[[Category: Lysozyme]]
+[[Category: Large Structures]]
-[[Category: Rowlett, R S.]]
+[[Category: Rowlett RS]]
-[[Category: Allergen]]
-[[Category: Antimicrobial]]
-[[Category: Bacteriolytic enzyme]]
-[[Category: Disulfide bond]]
-[[Category: Glycosidase]]
-[[Category: Hydrolase]]
-[[Category: Lysozyme]]
-[[Category: Rhenium tricarbonyl]]

3kam: Difference between revisions

Latest revision as of 06:23, 27 November 2024

Hen Egg White Lysozyme Derivatized with rhenium(I) diaquatricarbonyl cation

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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