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[[Image:3c7i.png|left|200px]]


{{STRUCTURE_3c7i|  PDB=3c7i  |  SCENE=  }}
==X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.==
 
<StructureSection load='3c7i' size='340' side='right'caption='[[3c7i]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3c7i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2huy 2huy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C7I FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=TVN:N-{(2R)-4-(METHYLAMINO)-4-OXO-2-[4-(PHOSPHONOOXY)BENZYL]BUTANOYL}-L-VALYL-L-ASPARTAMIDE'>TVN</scene></td></tr>
[[3c7i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2huy 2huy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C7I OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c7i OCA], [https://pdbe.org/3c7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c7i RCSB], [https://www.ebi.ac.uk/pdbsum/3c7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c7i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>  Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c7i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c7i ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Growth factor receptor-bound protein 2|Growth factor receptor-bound protein 2]]
*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017001728</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Benfield, A P.]]
[[Category: Large Structures]]
[[Category: Martin, S F.]]
[[Category: Benfield AP]]
[[Category: Constrained]]
[[Category: Martin SF]]
[[Category: Entropy]]
[[Category: Flexible]]
[[Category: Grb2-sh2]]
[[Category: Host-virus interaction]]
[[Category: Ligand preorganization]]
[[Category: Phosphoprotein]]
[[Category: Sh2 domain]]
[[Category: Sh3 domain]]
[[Category: Splicing]]
Retrieved from "https://proteopedia.org/3c7i"