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[[Image:1ofo.png|left|200px]]


{{STRUCTURE_1ofo|  PDB=1ofo  |  SCENE= }}
==Crystal Structure of the Tyrosine Regulated 3-Deoxy-D-Arabino-Heptulosonate-7-Phosphate Synthase from Saccharomyces Cerevisiae in Complex with 2-Phosphoglycolate==
 
<StructureSection load='1ofo' size='340' side='right'caption='[[1ofo]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
===CRYSTAL STRUCTURE OF THE TYROSINE REGULATED 3-DEOXY-D-ARABINO-HEPTULOSONATE-7-PHOSPHATE SYNTHASE FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH 2-PHOSPHOGLYCOLATE===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ofo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OFO FirstGlance]. <br>
{{ABSTRACT_PUBMED_15019786}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ofo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ofo OCA], [https://pdbe.org/1ofo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ofo RCSB], [https://www.ebi.ac.uk/pdbsum/1ofo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ofo ProSAT]</span></td></tr>
[[1ofo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OFO OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AROG_YEAST AROG_YEAST] Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/1ofo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ofo ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[DAHP synthase 3D structures|DAHP synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:015019786</ref><ref group="xtra">PMID:012540830</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: 3-deoxy-7-phosphoheptulonate synthase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Braus, G.]]
[[Category: Braus G]]
[[Category: Heinrich, G.]]
[[Category: Heinrich G]]
[[Category: Koenig, V.]]
[[Category: Koenig V]]
[[Category: Pfeil, A.]]
[[Category: Pfeil A]]
[[Category: Schneider, T R.]]
[[Category: Schneider TR]]
[[Category: Aldolase]]
[[Category: Aromatic amino-acid biosynthesis synthase]]
[[Category: Beta-alpha-barrel]]
[[Category: Lyase]]
[[Category: Manganese]]
[[Category: Synthetase]]
Retrieved from "https://proteopedia.org/1ofo"