1bdm: Difference between revisions

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[[Image:1bdm.png|left|200px]]


{{STRUCTURE_1bdm|  PDB=1bdm  |  SCENE=  }}
==THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY==
 
<StructureSection load='1bdm' size='340' side='right'caption='[[1bdm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===THE STRUCTURE AT 1.8 ANGSTROMS RESOLUTION OF A SINGLE SITE MUTANT (T189I) OF MALATE DEHYDROGENASE FROM THERMUS FLAVUS WITH INCREASED ENZYMATIC ACTIVITY===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1bdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BDM FirstGlance]. <br>
{{ABSTRACT_PUBMED_8471603}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAX:BETA-6-HYDROXY-1,4,5,6-TETRHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAX</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bdm OCA], [https://pdbe.org/1bdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bdm RCSB], [https://www.ebi.ac.uk/pdbsum/1bdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bdm ProSAT]</span></td></tr>
[[1bdm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BDM OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDH_THETH MDH_THETH] Catalyzes the reversible oxidation of malate to oxaloacetate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/1bdm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bdm ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Johnson sandbox 1|Johnson sandbox 1]]
*[[Malate Dehydrogenase 3D structures|Malate Dehydrogenase 3D structures]]
*[[Malate dehydrogenase|Malate dehydrogenase]]
__TOC__
 
</StructureSection>
==Reference==
[[Category: Large Structures]]
<ref group="xtra">PMID:008471603</ref><references group="xtra"/>
[[Category: Malate dehydrogenase]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Birktoft, J J.]]
[[Category: Birktoft JJ]]
[[Category: Kelly, C A.]]
[[Category: Kelly CA]]
Retrieved from "https://proteopedia.org/1bdm"