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[[Image:1a8h.png|left|200px]]


{{STRUCTURE_1a8h|  PDB=1a8h  |  SCENE=  }}
==METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS==
 
<StructureSection load='1a8h' size='340' side='right'caption='[[1a8h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1a8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8H FirstGlance]. <br>
{{ABSTRACT_PUBMED_10673435}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8h OCA], [https://pdbe.org/1a8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8h RCSB], [https://www.ebi.ac.uk/pdbsum/1a8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8h ProSAT], [https://www.topsan.org/Proteins/RSGI/1a8h TOPSAN]</span></td></tr>
[[1a8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8H OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYM_THET8 SYM_THET8] Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8h ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aminoacyl tRNA Synthetase|Aminoacyl tRNA Synthetase]]
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:010673435</ref><ref group="xtra">PMID:015048824</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Methionine--tRNA ligase]]
[[Category: Thermus thermophilus HB8]]
[[Category: Thermus thermophilus]]
[[Category: Giege R]]
[[Category: Giege, R.]]
[[Category: Konno M]]
[[Category: Konno, M.]]
[[Category: Kuwabara S]]
[[Category: Kuwabara, S.]]
[[Category: Lober B]]
[[Category: Lober, B.]]
[[Category: Moras D]]
[[Category: Moras, D.]]
[[Category: Nureki O]]
[[Category: Nureki, O.]]
[[Category: Sugiura I]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Ugaji Y]]
[[Category: Sugiura, I.]]
[[Category: Yokoyama S]]
[[Category: Ugaji, Y.]]
[[Category: Yokoyama, S.]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rossmann fold]]
[[Category: Rsgi]]
[[Category: Structural genomic]]

Latest revision as of 06:28, 7 February 2024

METHIONYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS

1a8h, resolution 2.00Å

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