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[[Image:2hro.png|left|200px]]


{{STRUCTURE_2hro|  PDB=2hro  |  SCENE=  }}
==Structure of the full-lenght Enzyme I of the PTS system from Staphylococcus carnosus==
 
<StructureSection load='2hro' size='340' side='right'caption='[[2hro]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Structure of the full-lenght Enzyme I of the PTS system from Staphylococcus carnosus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2hro]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_carnosus Staphylococcus carnosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HRO FirstGlance]. <br>
{{ABSTRACT_PUBMED_16867985}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hro OCA], [https://pdbe.org/2hro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hro RCSB], [https://www.ebi.ac.uk/pdbsum/2hro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hro ProSAT]</span></td></tr>
[[2hro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_carnosus Staphylococcus carnosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HRO OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PT1_STACT PT1_STACT] General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/2hro_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hro ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphotransferase|Phosphotransferase]]
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016867985</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Phosphoenolpyruvate--protein phosphotransferase]]
[[Category: Staphylococcus carnosus]]
[[Category: Staphylococcus carnosus]]
[[Category: Engelman, R.]]
[[Category: Engelman R]]
[[Category: Hengstenberg, W.]]
[[Category: Hengstenberg W]]
[[Category: Koch, B.]]
[[Category: Koch B]]
[[Category: Marquez, J A.]]
[[Category: Marquez JA]]
[[Category: Reinelt, S.]]
[[Category: Reinelt S]]
[[Category: Scheffzek, K.]]
[[Category: Scheffzek K]]
[[Category: Histidine phosphorylation]]
[[Category: Protein phosphorylation]]
[[Category: Pt]]
[[Category: Sugar transport]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2hro"