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[[Image:1fc3.png|left|200px]]


{{STRUCTURE_1fc3|  PDB=1fc3  |  SCENE=  }}
==THE CRYSTAL STRUCTURE OF TRANS-ACTIVATION DOMAIN OF THE SPORULATION RESPONSE REGULATOR, SPO0A==
 
<StructureSection load='1fc3' size='340' side='right'caption='[[1fc3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===THE CRYSTAL STRUCTURE OF TRANS-ACTIVATION DOMAIN OF THE SPORULATION RESPONSE REGULATOR, SPO0A===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1fc3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FC3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_11069648}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fc3 OCA], [https://pdbe.org/1fc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fc3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fc3 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1fc3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC3 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/SP0A_GEOSE SP0A_GEOSE] May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/1fc3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fc3 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Response regulator|Response regulator]]
*[[Response regulator 3D structure|Response regulator 3D structure]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:011069648</ref><references group="xtra"/>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Krzywda, S.]]
[[Category: Large Structures]]
[[Category: Lewis, R J.]]
[[Category: Krzywda S]]
[[Category: Wilkinson, A J.]]
[[Category: Lewis RJ]]
[[Category: Response regulator]]
[[Category: Wilkinson AJ]]
[[Category: Signaling protein]]
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