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[[Image:3onb.png|left|200px]]


{{STRUCTURE_3onb|  PDB=3onb  |  SCENE=  }}
==Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after extensive radiation dose==
 
<StructureSection load='3onb' size='340' side='right'caption='[[3onb]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
===Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after extensive radiation dose===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3onb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ONB FirstGlance]. <br>
{{ABSTRACT_PUBMED_21862860}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3onb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3onb OCA], [https://pdbe.org/3onb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3onb RCSB], [https://www.ebi.ac.uk/pdbsum/3onb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3onb ProSAT]</span></td></tr>
[[3onb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONB OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


==See Also==
==See Also==
*[[Aldose Reductase|Aldose Reductase]]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021862860</ref><references group="xtra"/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Heine, A.]]
[[Category: Large Structures]]
[[Category: Klebe, G.]]
[[Category: Heine A]]
[[Category: Koch, C.]]
[[Category: Klebe G]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Koch C]]
[[Category: Radiation damage]]
[[Category: T113a mutant]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/3onb"