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[[Image:1ohu.png|left|200px]]


{{STRUCTURE_1ohu|  PDB=1ohu  |  SCENE= }}
==Structure of Caenorhabditis elegans CED-9==
 
<StructureSection load='1ohu' size='340' side='right'caption='[[1ohu]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
===STRUCTURE OF CAENORHABDITIS ELEGANS CED-9===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1ohu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OHU FirstGlance]. <br>
{{ABSTRACT_PUBMED_12894216}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ohu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ohu OCA], [https://pdbe.org/1ohu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ohu RCSB], [https://www.ebi.ac.uk/pdbsum/1ohu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ohu ProSAT]</span></td></tr>
[[1ohu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OHU OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CED9_CAEEL CED9_CAEEL] Plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3.<ref>PMID:7907274</ref> <ref>PMID:9024666</ref> <ref>PMID:9027313</ref> <ref>PMID:9604928</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oh/1ohu_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ohu ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cell death protein|Cell death protein]]
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012894216</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Ha, N C.]]
[[Category: Large Structures]]
[[Category: Jeong, J S.]]
[[Category: Ha N-C]]
[[Category: Oh, B H.]]
[[Category: Jeong J-S]]
[[Category: Apoptosis]]
[[Category: Oh B-H]]
[[Category: Bcl-2 family]]
[[Category: Ced-9]]
Retrieved from "https://proteopedia.org/1ohu"