3k75: Difference between revisions

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[[Image:3k75.png|left|200px]]


{{STRUCTURE_3k75|  PDB=3k75  |  SCENE=  }}
==X-ray crystal structure of reduced XRCC1 bound to DNA pol beta catalytic domain==
 
<StructureSection load='3k75' size='340' side='right'caption='[[3k75]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
===X-ray crystal structure of reduced XRCC1 bound to DNA pol beta catalytic domain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3k75]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K75 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K75 FirstGlance]. <br>
{{ABSTRACT_PUBMED_20351257}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k75 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k75 OCA], [https://pdbe.org/3k75 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k75 RCSB], [https://www.ebi.ac.uk/pdbsum/3k75 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k75 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3k75]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K75 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/XRCC1_HUMAN XRCC1_HUMAN] Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k75_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k75 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020351257</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Cuneo, M J.]]
[[Category: Cuneo MJ]]
[[Category: London, R E.]]
[[Category: London RE]]
[[Category: Allosteric disulfide]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Dna replication]]
[[Category: Dna synthesis]]
[[Category: Dna-binding]]
[[Category: Dna-binding protein]]
[[Category: Dna-directed dna polymerase]]
[[Category: Lyase]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Methylation]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Pol beta]]
[[Category: Transferase]]
[[Category: Xrcc1]]
Retrieved from "https://proteopedia.org/3k75"