4dbu: Difference between revisions

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[[Image:4dbu.png|left|200px]]


{{STRUCTURE_4dbu|  PDB=4dbu  |  SCENE=  }}
==Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid==
 
<StructureSection load='4dbu' size='340' side='right'caption='[[4dbu]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3) in complex with NADP+ and 3-((4 -(trifluoromethyl)phenyl)amino)benzoic acid===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4dbu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBU FirstGlance]. <br>
{{ABSTRACT_PUBMED_22507964}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.528&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BT9:3-{[4-(TRIFLUOROMETHYL)PHENYL]AMINO}BENZOIC+ACID'>BT9</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbu OCA], [https://pdbe.org/4dbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbu RCSB], [https://www.ebi.ac.uk/pdbsum/4dbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbu ProSAT]</span></td></tr>
[[4dbu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBU OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.


==See Also==
==See Also==
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022507964</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, M.]]
[[Category: Large Structures]]
[[Category: Christianson, D W.]]
[[Category: Chen M]]
[[Category: Penning, T M.]]
[[Category: Christianson DW]]
[[Category: Winkler, J D.]]
[[Category: Penning TM]]
[[Category: Akr1c3 selective inhibitor]]
[[Category: Winkler JD]]
[[Category: Castrate resistant prostate cancer]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Steroid metabolism]]
[[Category: Tim barrel]]
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