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[[Image:3ick.png|left|200px]]


{{STRUCTURE_3ick|  PDB=3ick  |  SCENE=  }}
==Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with minodronate and isopentenyl disphosphate==
 
<StructureSection load='3ick' size='340' side='right'caption='[[3ick]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Trypanosoma cruzi farnesyl diphosphate synthase homodimer in complex with minodronate and isopentenyl disphosphate===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ick]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ICK FirstGlance]. <br>
{{ABSTRACT_PUBMED_19876942}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=M0N:(1-HYDROXY-2-IMIDAZO[1,2-A]PYRIDIN-3-YLETHANE-1,1-DIYL)BIS(PHOSPHONIC+ACID)'>M0N</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ick FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ick OCA], [https://pdbe.org/3ick PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ick RCSB], [https://www.ebi.ac.uk/pdbsum/3ick PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ick ProSAT]</span></td></tr>
[[3ick]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ICK OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q95WL3_TRYCR Q95WL3_TRYCR]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ic/3ick_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ick ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]]
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:019876942</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Geranyltranstransferase]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
[[Category: Amzel, L M.]]
[[Category: Amzel LM]]
[[Category: Gabelli, S B.]]
[[Category: Gabelli SB]]
[[Category: Huang, C H.]]
[[Category: Huang CH]]
[[Category: Oldfield, E.]]
[[Category: Oldfield E]]
[[Category: Bisphosphonate]]
[[Category: Chagas disease]]
[[Category: Farnesyl diphosphate synthase]]
[[Category: Fpp]]
[[Category: Isoprene biosynthesis]]
[[Category: Minodronate]]
[[Category: Risedronate]]
[[Category: Transferase]]
[[Category: Zoledronate]]
Retrieved from "https://proteopedia.org/3ick"