3c0t: Difference between revisions
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==Structure of the Schizosaccharomyces pombe Mediator subcomplex Med8C/18== | |||
<StructureSection load='3c0t' size='340' side='right'caption='[[3c0t]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3c0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C0T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c0t OCA], [https://pdbe.org/3c0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c0t RCSB], [https://www.ebi.ac.uk/pdbsum/3c0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c0t ProSAT]</span></td></tr> | |||
== | </table> | ||
[[3c0t]] is a 2 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/MED18_SCHPO MED18_SCHPO] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:12471453</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/3c0t_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c0t ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Mediator|Mediator]] | *[[Mediator|Mediator]] | ||
== References == | |||
== | <references/> | ||
< | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
[[Category: Cramer | [[Category: Cramer P]] | ||
[[Category: Feldmann | [[Category: Feldmann H]] | ||
[[Category: Hahn | [[Category: Hahn S]] | ||
[[Category: Holstege | [[Category: Holstege CP]] | ||
[[Category: Lariviere | [[Category: Lariviere L]] | ||
[[Category: Roether S]] | |||
[[Category: Roether | [[Category: Seizl M]] | ||
[[Category: Seizl | [[Category: Straesser K]] | ||
[[Category: Straesser | [[Category: Van Wageningen S]] | ||
[[Category: Wageningen | [[Category: Van de Pasch L]] | ||
[[Category: | |||
