2oiu: Difference between revisions

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[[Image:2oiu.png|left|200px]]


{{STRUCTURE_2oiu| PDB=2oiu | SCENE= }}
==L1 Ribozyme Ligase circular adduct==
<StructureSection load='2oiu' size='340' side='right'caption='[[2oiu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2oiu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oiu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oiu OCA], [https://pdbe.org/2oiu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oiu RCSB], [https://www.ebi.ac.uk/pdbsum/2oiu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oiu ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5' to 3' phosphodiester bond between the 5'-triphosphate and the 3'-hydroxyl termini of two RNA fragments. Invariant residues form tertiary contacts that stabilize a flexible stem of the ribozyme at the ligation site, where an essential magnesium ion coordinates three phosphates. The structure of the active site permits us to suggest how transition-state stabilization and a general base may catalyze the ligation reaction required for prebiotic RNA assembly.


===L1 Ribozyme Ligase circular adduct===
The structural basis of ribozyme-catalyzed RNA assembly.,Robertson MP, Scott WG Science. 2007 Mar 16;315(5818):1549-53. PMID:17363667<ref>PMID:17363667</ref>


{{ABSTRACT_PUBMED_17363667}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 2oiu" style="background-color:#fffaf0;"></div>
[[2oiu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIU OCA].


==See Also==
==See Also==
*[[Ribozyme|Ribozyme]]
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017363667</ref><references group="xtra"/>
__TOC__
[[Category: Robertson, M P]]
</StructureSection>
[[Category: Scott, W G.]]
[[Category: Large Structures]]
[[Category: Active site]]
[[Category: Robertson MP]]
[[Category: In vitro selection]]
[[Category: Scott WG]]
[[Category: Ligase]]
[[Category: Ribozyme]]
[[Category: Rna]]
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