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[[Image:2ipc.png|left|200px]]


{{STRUCTURE_2ipc|  PDB=2ipc  |  SCENE=  }}
==Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer==
 
<StructureSection load='2ipc' size='340' side='right'caption='[[2ipc]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
===Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ipc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IPC FirstGlance]. <br>
{{ABSTRACT_PUBMED_17059823}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ipc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipc OCA], [https://pdbe.org/2ipc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ipc RCSB], [https://www.ebi.ac.uk/pdbsum/2ipc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ipc ProSAT], [https://www.topsan.org/Proteins/RSGI/2ipc TOPSAN]</span></td></tr>
==About this Structure==
</table>
[[2ipc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPC OCA].  
== Function ==
[https://www.uniprot.org/uniprot/SECA_THET8 SECA_THET8] Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.[HAMAP-Rule:MF_01382]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/2ipc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ipc ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Preprotein translocase 3D structures|Preprotein translocase 3D structures]]
*[[SecA|SecA]]
*[[SecA|SecA]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:017059823</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus HB8]]
[[Category: Ito, K.]]
[[Category: Ito K]]
[[Category: Kimura, Y.]]
[[Category: Kimura Y]]
[[Category: Mori, H.]]
[[Category: Mori H]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Tahirov TH]]
[[Category: Tahirov, T H.]]
[[Category: Tsukazaki T]]
[[Category: Tsukazaki, T.]]
[[Category: Vassylyev DG]]
[[Category: Vassylyev, D G.]]
[[Category: Vassylyeva MN]]
[[Category: Vassylyeva, M N.]]
[[Category: Atpase]]
[[Category: Nucleotide binding fold]]
[[Category: Parallel dimer]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/2ipc"