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[[Image:2gfx.png|left|200px]]


{{STRUCTURE_2gfx|  PDB=2gfx  |  SCENE=  }}
==Structure of E. coli FabF(C163Q) in complex with Platensimycin==
 
<StructureSection load='2gfx' size='340' side='right'caption='[[2gfx]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
===Structure of E. coli FabF(C163Q) in complex with Platensimycin===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2gfx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GFX FirstGlance]. <br>
{{ABSTRACT_PUBMED_16710421}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PMN:PLATENSIMYCIN'>PMN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gfx OCA], [https://pdbe.org/2gfx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gfx RCSB], [https://www.ebi.ac.uk/pdbsum/2gfx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gfx ProSAT]</span></td></tr>
[[2gfx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFX OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/FABF_ECOLI FABF_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/2gfx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gfx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Acyl carrier protein synthase|Acyl carrier protein synthase]]
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:016710421</ref><references group="xtra"/>
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Parthasarathy, G.]]
[[Category: Large Structures]]
[[Category: Soisson, S M.]]
[[Category: Parthasarathy G]]
[[Category: Fabf]]
[[Category: Soisson SM]]
[[Category: Kasii]]
[[Category: Ketoacyl synthase]]
[[Category: Platensimycin]]
[[Category: Transferase]]

Latest revision as of 09:27, 14 February 2024

Structure of E. coli FabF(C163Q) in complex with Platensimycin

2gfx, resolution 2.59Å

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