3l3l: Difference between revisions

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[[Image:3l3l.png|left|200px]]


{{STRUCTURE_3l3l|  PDB=3l3l  |  SCENE=  }}
==PARP complexed with A906894==
 
<StructureSection load='3l3l' size='340' side='right'caption='[[3l3l]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===PARP complexed with A906894===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3l3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L3L FirstGlance]. <br>
{{ABSTRACT_PUBMED_20045315}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L3L:3-OXO-2-PIPERIDIN-4-YL-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDE'>L3L</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l3l OCA], [https://pdbe.org/3l3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l3l RCSB], [https://www.ebi.ac.uk/pdbsum/3l3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l3l ProSAT]</span></td></tr>
[[3l3l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L3L OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>


==See Also==
==See Also==
*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:020045315</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Park, C H.]]
[[Category: Large Structures]]
[[Category: Adp-ribosylation]]
[[Category: Park CH]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: Dna-binding]]
[[Category: Glycosyltransferase]]
[[Category: Metal-binding]]
[[Category: Nad]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Protein-inhibitor complex]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
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