3ll8: Difference between revisions

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[[Image:3ll8.png|left|200px]]


{{STRUCTURE_3ll8|  PDB=3ll8  |  SCENE=  }}
==Crystal Structure of Calcineurin in Complex with AKAP79 Peptide==
 
<StructureSection load='3ll8' size='340' side='right'caption='[[3ll8]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
===Crystal Structure of Calcineurin in Complex with AKAP79 Peptide===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3ll8]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LL8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_22343722}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ll8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ll8 OCA], [https://pdbe.org/3ll8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ll8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ll8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ll8 ProSAT]</span></td></tr>
[[3ll8]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LL8 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/AKAP5_HUMAN AKAP5_HUMAN] May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.


==See Also==
==See Also==
*[[Calcineurin|Calcineurin]]
*[[Calcineurin 3D structures|Calcineurin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:022343722</ref><ref group="xtra">PMID:008524402</ref><ref group="xtra">PMID:017498738</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Large Structures]]
[[Category: Hogan, P G.]]
[[Category: Hogan PG]]
[[Category: Li, H.]]
[[Category: Li H]]
[[Category: Akap79]]
[[Category: Beta-augmentation]]
[[Category: Calcineurin]]
[[Category: Calmodulin-binding]]
[[Category: Hydrolase]]
[[Category: Hydrolase-calcium binding protein complex]]
[[Category: Iron]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Myristate]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Protein phosphatase]]
[[Category: Protein targeting]]
[[Category: Protein-peptide docking]]
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