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[[Image:1rf8.png|left|200px]]


{{STRUCTURE_1rf8|  PDB=1rf8  |  SCENE=  }}
==Solution structure of the yeast translation initiation factor eIF4E in complex with m7GDP and eIF4GI residues 393 to 490==
 
<StructureSection load='1rf8' size='340' side='right'caption='[[1rf8]]' scene=''>
===Solution structure of the yeast translation initiation factor eIF4E in complex with m7GDP and eIF4GI residues 393 to 490===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1rf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RF8 FirstGlance]. <br>
{{ABSTRACT_PUBMED_14675538}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=MTN:S-[(1-OXYL-2,2,5,5-TETRAMETHYL-2,5-DIHYDRO-1H-PYRROL-3-YL)METHYL]+METHANESULFONOTHIOATE'>MTN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rf8 OCA], [https://pdbe.org/1rf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rf8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rf8 ProSAT]</span></td></tr>
[[1rf8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RF8 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/1rf8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rf8 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Eukaryotic initiation factor|Eukaryotic initiation factor]]
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:014675538</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Gross, J D.]]
[[Category: Gross JD]]
[[Category: Haar, T von der.]]
[[Category: Lugovskoy AA]]
[[Category: Lugovskoy, A A.]]
[[Category: McCarthy JEG]]
[[Category: McCarthy, J E.G.]]
[[Category: Moerke NJ]]
[[Category: Moerke, N J.]]
[[Category: Sachs AB]]
[[Category: Sachs, A B.]]
[[Category: Wagner G]]
[[Category: Wagner, G.]]
[[Category: Von der Haar T]]
[[Category: Biosynthetic protein]]
[[Category: Initiation factor]]
[[Category: Protein biosynthesis]]
[[Category: Translation]]
[[Category: Translation regulation]]
Retrieved from "https://proteopedia.org/1rf8"