2r8p: Difference between revisions

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[[Image:2r8p.png|left|200px]]


{{STRUCTURE_2r8p|  PDB=2r8p  |  SCENE=  }}
==Transketolase from E. coli in complex with substrate D-fructose-6-phosphate==
 
<StructureSection load='2r8p' size='340' side='right'caption='[[2r8p]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
===Transketolase from E. coli in complex with substrate D-fructose-6-phosphate===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2r8p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R8P FirstGlance]. <br>
{{ABSTRACT_PUBMED_17914867}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=T6F:2-C-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-5-(2-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-2-YL}-6-O-PHOSPHONO-D-GLUCITOL'>T6F</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r8p OCA], [https://pdbe.org/2r8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r8p RCSB], [https://www.ebi.ac.uk/pdbsum/2r8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r8p ProSAT]</span></td></tr>
[[2r8p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R8P OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/TKT1_ECOLI TKT1_ECOLI] Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.<ref>PMID:17914867</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/2r8p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r8p ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Transketolase|Transketolase]]
*[[Transketolase 3D structures|Transketolase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017914867</ref><references group="xtra"/>
__TOC__
[[Category: Escherichia coli k-12]]
</StructureSection>
[[Category: Transketolase]]
[[Category: Escherichia coli K-12]]
[[Category: Asztalos, P.]]
[[Category: Large Structures]]
[[Category: Tittmann, K.]]
[[Category: Asztalos P]]
[[Category: Weiss, M S.]]
[[Category: Tittmann K]]
[[Category: Wille, G.]]
[[Category: Weiss MS]]
[[Category: Metal-binding]]
[[Category: Wille G]]
[[Category: Reaction intermediate]]
[[Category: Thiamine pyrophosphate]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2r8p"