3alx: Difference between revisions

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[[Image:3alx.png|left|200px]]


{{STRUCTURE_3alx| PDB=3alx | SCENE= }}
==Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (MV-H(L482R)-SLAM(N102H/R108Y) fusion)==
<StructureSection load='3alx' size='340' side='right'caption='[[3alx]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3alx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_morbillivirus Measles morbillivirus], [https://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alx OCA], [https://pdbe.org/3alx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alx RCSB], [https://www.ebi.ac.uk/pdbsum/3alx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/E2RZS2_9MONO E2RZS2_9MONO] [https://www.uniprot.org/uniprot/Q9GJT3_SAGOE Q9GJT3_SAGOE]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a beta-sheet of the membrane-distal ectodomain of SLAM using the side of its beta-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their beta-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H-SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.


===Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (MV-H(L482R)-SLAM(N102H/R108Y) fusion)===
Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.,Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y Nat Struct Mol Biol. 2011 Feb;18(2):135-41. Epub 2011 Jan 9. PMID:21217702<ref>PMID:21217702</ref>


{{ABSTRACT_PUBMED_21217702}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 3alx" style="background-color:#fffaf0;"></div>
[[3alx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALX OCA].


==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021217702</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Measles morbillivirus]]
[[Category: Saguinus oedipus]]
[[Category: Saguinus oedipus]]
[[Category: Hashiguchi, T.]]
[[Category: Synthetic construct]]
[[Category: Kamishikiryo, J.]]
[[Category: Hashiguchi T]]
[[Category: Kubota, M.]]
[[Category: Kamishikiryo J]]
[[Category: Maenaka, K.]]
[[Category: Kubota M]]
[[Category: Maita, N.]]
[[Category: Maenaka K]]
[[Category: Ose, T.]]
[[Category: Maita N]]
[[Category: Yanagi, Y.]]
[[Category: Ose T]]
[[Category: Beta-sandwich]]
[[Category: Yanagi Y]]
[[Category: Immunoglobulin fold]]
[[Category: Six-bladed beta-propeller fold]]
[[Category: Viral protein-membrane protein complex]]
[[Category: Viral protein-receptor complex]]
Retrieved from "https://proteopedia.org/3alx"