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[[Image:2kzt.png|left|200px]]


{{STRUCTURE_2kzt|  PDB=2kzt  |  SCENE=  }}
==Structure of the Tandem MA-3 Region of Pdcd4==
 
<StructureSection load='2kzt' size='340' side='right'caption='[[2kzt]]' scene=''>
===Structure of the Tandem MA-3 Region of Pdcd4===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2kzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZT FirstGlance]. <br>
{{ABSTRACT_PUBMED_21454508}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzt OCA], [https://pdbe.org/2kzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzt RCSB], [https://www.ebi.ac.uk/pdbsum/2kzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzt ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2kzt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZT OCA].  
== Function ==
[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>


==See Also==
==See Also==
*[[Cell death protein|Cell death protein]]
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021454508</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Banerjee, S.]]
[[Category: Banerjee S]]
[[Category: Carr, M D.]]
[[Category: Carr MD]]
[[Category: Henry, A J.]]
[[Category: Henry AJ]]
[[Category: Klempnauer, K H.]]
[[Category: Klempnauer KH]]
[[Category: Muskett, F W.]]
[[Category: Muskett FW]]
[[Category: Oka, O.]]
[[Category: Oka O]]
[[Category: Schmedt, T.]]
[[Category: Schmedt T]]
[[Category: Strong, S L.]]
[[Category: Strong SL]]
[[Category: Veverka, V.]]
[[Category: Veverka V]]
[[Category: Waters, L C.]]
[[Category: Waters LC]]
[[Category: Apoptosis]]
[[Category: Eif4a]]
[[Category: Heat]]
[[Category: Ma-3]]
[[Category: Pdcd4]]
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