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[[Image:2x4f.png|left|200px]]


{{STRUCTURE_2x4f|  PDB=2x4f  |  SCENE= }}
==The Crystal Structure of the human myosin light chain kinase LOC340156.==
 
<StructureSection load='2x4f' size='340' side='right'caption='[[2x4f]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
===THE CRYSTAL STRUCTURE OF THE HUMAN MYOSIN LIGHT CHAIN KINASE LOC340156.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2x4f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4F FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16X:4-(2-AMINO-4-METHYL-1,3-THIAZOL-5-YL)-N-(3-DIOXAZIRIDIN-3-YLPHENYL)PYRIMIDIN-2-AMINE'>16X</scene>, <scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[2x4f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4F OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4f OCA], [https://pdbe.org/2x4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4f RCSB], [https://www.ebi.ac.uk/pdbsum/2x4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4f ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MYLK4_HUMAN MYLK4_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4f_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4f ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Myosin light chain kinase|Myosin light chain kinase]]
*[[Myosin light chain kinase|Myosin light chain kinase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Chaikuad, A.]]
[[Category: Chaikuad A]]
[[Category: Cocking, R.]]
[[Category: Cocking R]]
[[Category: Daga, N.]]
[[Category: Daga N]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Elkins, J M.]]
[[Category: Elkins JM]]
[[Category: Fedorov, O.]]
[[Category: Fedorov O]]
[[Category: Gileadi, O.]]
[[Category: Gileadi O]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Krojer, T.]]
[[Category: Krojer T]]
[[Category: Mahajan, P.]]
[[Category: Mahajan P]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Rellos, P.]]
[[Category: Rellos P]]
[[Category: Shrestha, B.]]
[[Category: Shrestha B]]
[[Category: Ugochukwu, E.]]
[[Category: Ugochukwu E]]
[[Category: Vondelft, F.]]
[[Category: Wang J]]
[[Category: Wang, J.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Yue W]]
[[Category: Yue, W.]]
[[Category: Von Delft F]]
[[Category: Breast cancer]]
[[Category: Kinase]]
[[Category: Lung]]
[[Category: Myosin]]
[[Category: Nucleotide-binding]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2x4f"