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[[Image:3g43.png|left|200px]]


{{STRUCTURE_3g43|  PDB=3g43  |  SCENE=  }}
==Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer==
 
<StructureSection load='3g43' size='340' side='right'caption='[[3g43]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Crystal structure of the calmodulin-bound Cav1.2 C-terminal regulatory domain dimer===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3g43]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G43 FirstGlance]. <br>
{{ABSTRACT_PUBMED_19279214}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g43 OCA], [https://pdbe.org/3g43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g43 RCSB], [https://www.ebi.ac.uk/pdbsum/3g43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g43 ProSAT]</span></td></tr>
[[3g43]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G43 OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of CPVT4.  The disease is caused by mutations affecting the gene represented in this entry. Mutations in CALM1 are the cause of LQT14.
== Function ==
[https://www.uniprot.org/uniprot/CALM1_HUMAN CALM1_HUMAN] Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696).<ref>PMID:16760425</ref> <ref>PMID:23893133</ref> <ref>PMID:26969752</ref> <ref>PMID:27165696</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g43_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g43 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Calmodulin|Calmodulin]]
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
*[[Ion channels|Ion channels]]
*[[Ion channels 3D structures|Ion channels 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019279214</ref><ref group="xtra">PMID:016338416</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fallon, J L.]]
[[Category: Large Structures]]
[[Category: Quiocho, F A.]]
[[Category: Fallon JL]]
[[Category: Brugada syndrome]]
[[Category: Quiocho FA]]
[[Category: Calcium channel]]
[[Category: Calcium transport]]
[[Category: Calmodulin-bound]]
[[Category: Disease mutation]]
[[Category: Glycoprotein]]
[[Category: Ion transport]]
[[Category: Ionic channel]]
[[Category: Membrane]]
[[Category: Metal binding protein]]
[[Category: Methylation]]
[[Category: Phosphoprotein]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Voltage-gated channel]]
Retrieved from "https://proteopedia.org/3g43"