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[[Image:1mem.png|left|200px]]


{{STRUCTURE_1mem|  PDB=1mem  |  SCENE=  }}
==Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor==
 
<StructureSection load='1mem' size='340' side='right'caption='[[1mem]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal structure of Cathepsin K complexed with a potent vinyl sulfone inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1mem]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MEM FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0D6:N-{(1R)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}-N~2~-(PIPERAZIN-1-YLCARBONYL)-L-LEUCINAMIDE'>0D6</scene></td></tr>
[[1mem]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEM OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mem OCA], [https://pdbe.org/1mem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mem RCSB], [https://www.ebi.ac.uk/pdbsum/1mem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mem ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[https://omim.org/entry/265800 265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
== Function ==
[https://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/1mem_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mem ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cathepsin|Cathepsin]]
*[[Cathepsin 3D structures|Cathepsin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:009033587</ref><references group="xtra"/>
__TOC__
[[Category: Cathepsin K]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mcgrath, M E.]]
[[Category: Large Structures]]
[[Category: Cysteine]]
[[Category: Mcgrath ME]]
[[Category: Disease mutation]]
[[Category: Disulfide bond]]
[[Category: Drug design]]
[[Category: Glycoprotein]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Lysosome]]
[[Category: Osteoclast]]
[[Category: Osteoporosis]]
[[Category: Protease]]
[[Category: Thiol protease]]
[[Category: Zymogen]]
Retrieved from "https://proteopedia.org/1mem"