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[[Image:3gro.png|left|200px]]


{{STRUCTURE_3gro|  PDB=3gro  |  SCENE=  }}
==Human palmitoyl-protein thioesterase 1==
 
<StructureSection load='3gro' size='340' side='right'caption='[[3gro]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
===Human palmitoyl-protein thioesterase 1===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3gro]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GRO FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
[[3gro]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GRO OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gro OCA], [https://pdbe.org/3gro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gro RCSB], [https://www.ebi.ac.uk/pdbsum/3gro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gro ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PPT1_HUMAN PPT1_HUMAN] CLN1 disease. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:7637805</ref> <ref>PMID:9425237</ref> <ref>PMID:9664077</ref> <ref>PMID:11506414</ref> <ref>PMID:19201763</ref> <ref>PMID:21990111</ref>
== Function ==
[https://www.uniprot.org/uniprot/PPT1_HUMAN PPT1_HUMAN] Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/3gro_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gro ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Thioesterase|Thioesterase]]
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Palmitoyl-protein hydrolase]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev A]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Cossar, D.]]
[[Category: Cossar D]]
[[Category: Dobrovetsky, E.]]
[[Category: Dobrovetsky E]]
[[Category: Dong, A.]]
[[Category: Dong A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Park, H.]]
[[Category: Park H]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Seitova A]]
[[Category: Seitova, A.]]
[[Category: Tempel W]]
[[Category: Tempel, W.]]
[[Category: Tong Y]]
[[Category: Tong, Y.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Disease mutation]]
[[Category: Disulfide bond]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Lysosome]]
[[Category: Neurodegeneration]]
[[Category: Neuronal ceroid lipofuscinosis]]
[[Category: Sensory transduction]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Vision]]
Retrieved from "https://proteopedia.org/3gro"