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[[Image:1m18.png|left|200px]]


{{STRUCTURE_1m18|  PDB=1m18  |  SCENE=  }}
==LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA==
 
<StructureSection load='1m18' size='340' side='right'caption='[[1m18]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
===LIGAND BINDING ALTERS THE STRUCTURE AND DYNAMICS OF NUCLEOSOMAL DNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1m18]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M18 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12559907}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1SZ:N-[5-[[4-[[5-[[5-[[5-[[5-[[3-[3-(DIMETHYLAMINO)PROPYLAMINO]-3-OXIDANYLIDENE-PROPYL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]AMINO]-4-OXIDANYLIDENE-BUTYL]CARBAMOYL]-1-METHYL-PYRROL-3-YL]-1-METHYL-4-[[1-METHYL-4-[(1-METHYLIMIDAZOL-2-YL)CARBONYLAMINO]PYRROL-2-YL]CARBONYLAMINO]IMIDAZOLE-2-CARBOXAMIDE'>1SZ</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m18 OCA], [https://pdbe.org/1m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m18 RCSB], [https://www.ebi.ac.uk/pdbsum/1m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m18 ProSAT]</span></td></tr>
[[1m18]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M18 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/H3C_XENLA H3C_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m18_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m18 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Histone|Histone]]
*[[Histone 3D structures|Histone 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012559907</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
[[Category: Dervan, P B.]]
[[Category: Dervan PB]]
[[Category: Edayathumangalam, R S.]]
[[Category: Edayathumangalam RS]]
[[Category: Gottesfeld, J M.]]
[[Category: Gottesfeld JM]]
[[Category: Luger, K.]]
[[Category: Luger K]]
[[Category: Melander, C.]]
[[Category: Melander C]]
[[Category: Suto, R K.]]
[[Category: Suto RK]]
[[Category: White, C L.]]
[[Category: White CL]]
[[Category: Chromatin]]
[[Category: Chromatin remodeling]]
[[Category: Dna regognition]]
[[Category: Histone]]
[[Category: Nucleosome]]
[[Category: Pyrrole-imidazole polyamide]]
[[Category: Structural protein-dna complex]]
Retrieved from "https://proteopedia.org/1m18"