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[[Image:3mwp.png|left|200px]]


{{STRUCTURE_3mwp|  PDB=3mwp  |  SCENE=  }}
==Nucleoprotein structure of lassa fever virus==
 
<StructureSection load='3mwp' size='340' side='right'caption='[[3mwp]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
===Nucleoprotein structure of lassa fever virus===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3mwp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_virus_Josiah Lassa virus Josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MWP FirstGlance]. <br>
{{ABSTRACT_PUBMED_21085117}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.795&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mwp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mwp OCA], [https://pdbe.org/3mwp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mwp RCSB], [https://www.ebi.ac.uk/pdbsum/3mwp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mwp ProSAT]</span></td></tr>
[[3mwp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lassa_virus_josiah Lassa virus josiah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MWP OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity).


==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021085117</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Lassa virus josiah]]
[[Category: Lassa virus Josiah]]
[[Category: Dong, C.]]
[[Category: Dong C]]
[[Category: Dong, H.]]
[[Category: Dong H]]
[[Category: Lan, S.]]
[[Category: Lan S]]
[[Category: Liang, Y.]]
[[Category: Liang Y]]
[[Category: Ly, H.]]
[[Category: Ly H]]
[[Category: Qi, X.]]
[[Category: Qi X]]
[[Category: SSPF, Scottish Structural Proteomics Facility.]]
[[Category: Schelde LM]]
[[Category: Schelde, L M.]]
[[Category: Wallat G]]
[[Category: Wallat, G.]]
[[Category: Wang W]]
[[Category: Wang, W.]]
[[Category: Nuclear protein]]
[[Category: Nucleoprotein]]
[[Category: Scottish structural proteomics facility]]
[[Category: Sspf]]
[[Category: Structural genomic]]
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