3q02: Difference between revisions

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[[Image:3q02.png|left|200px]]


{{STRUCTURE_3q02|  PDB=3q02  |  SCENE=  }}
==Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.==
 
<StructureSection load='3q02' size='340' side='right'caption='[[3q02]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3q02]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q02 FirstGlance]. <br>
{{ABSTRACT_PUBMED_21697084}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q02 OCA], [https://pdbe.org/3q02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q02 RCSB], [https://www.ebi.ac.uk/pdbsum/3q02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q02 ProSAT]</span></td></tr>
[[3q02]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q02 OCA].  
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref>  Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
== Function ==
[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>


==See Also==
==See Also==
*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:021697084</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Jensen, J K]]
[[Category: Large Structures]]
[[Category: Morth, J P.]]
[[Category: Jensen JK]]
[[Category: Active serpin]]
[[Category: Morth JP]]
[[Category: Hydrolase inhibitor]]
[[Category: Metastable conformation]]
[[Category: Pai-1]]
[[Category: Serine protease inhibitor]]
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