3m2l: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3m2l.png|left|200px]]


{{STRUCTURE_3m2l|  PDB=3m2l  |  SCENE=  }}
==Crystal structure of the M113F mutant of alpha-hemolysin==
 
<StructureSection load='3m2l' size='340' side='right'caption='[[3m2l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Crystal structure of the M113F mutant of alpha-hemolysin===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3m2l]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M2L FirstGlance]. <br>
{{ABSTRACT_PUBMED_20400691}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m2l OCA], [https://pdbe.org/3m2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m2l RCSB], [https://www.ebi.ac.uk/pdbsum/3m2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m2l ProSAT]</span></td></tr>
==About this Structure==
</table>
[[3m2l]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M2L OCA].  
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/3m2l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m2l ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Hemolysin|Hemolysin]]
*[[Hemolysin 3D structures|Hemolysin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:020400691</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Gouaux, E.]]
[[Category: Gouaux E]]
[[Category: Montoya, M.]]
[[Category: Montoya M]]
[[Category: Beta barrel]]
[[Category: Cytolysis]]
[[Category: Hemolysis]]
[[Category: Pore-forming toxin]]
[[Category: Secreted]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/3m2l"