3t5g: Difference between revisions

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[[Image:3t5g.png|left|200px]]


{{STRUCTURE_3t5g|  PDB=3t5g  |  SCENE=  }}
==Structure of fully modified farnesylated Rheb in complex with PDE6D==
 
<StructureSection load='3t5g' size='340' side='right'caption='[[3t5g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Structure of fully modified farnesylated Rheb in complex with PDE6D===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3t5g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5G FirstGlance]. <br>
{{ABSTRACT_PUBMED_22002721}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene>, <scene name='pdbligand=FAR:FARNESYL'>FAR</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5g OCA], [https://pdbe.org/3t5g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5g RCSB], [https://www.ebi.ac.uk/pdbsum/3t5g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5g ProSAT]</span></td></tr>
[[3t5g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5G OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/RHEB_HUMAN RHEB_HUMAN] Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity.<ref>PMID:12271141</ref> <ref>PMID:12869586</ref> <ref>PMID:15340059</ref> <ref>PMID:15854902</ref> <ref>PMID:16098514</ref> <ref>PMID:20381137</ref>


==See Also==
==See Also==
*[[Phosphodiesterase|Phosphodiesterase]]
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:022002721</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, Y X.]]
[[Category: Large Structures]]
[[Category: Ismail, S A.]]
[[Category: Chen Y-X]]
[[Category: Wittinghofer, A.]]
[[Category: Ismail SA]]
[[Category: Farnesyl]]
[[Category: Wittinghofer A]]
[[Category: Immunoglobulin-like beta sandwitch]]
[[Category: Lipid binding protein]]
[[Category: Pde delta]]
[[Category: Rheb]]
[[Category: Signaling protein]]
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