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[[Image:1n5b.gif|left|200px]]<br /><applet load="1n5b" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1n5b, resolution 2.00&Aring;" />
'''Crystal Structure Of The Yersinia enterocolitica Molecular Chaperone Syce'''<br />


==Overview==
==Crystal Structure Of The Yersinia enterocolitica Molecular Chaperone Syce==
The crystal structure of the Yersinia enterocolitica molecular-chaperone protein SycE, which specifically binds the YopE protein, has been solved to 2.0 A resolution by molecular replacement. The crystal contains two SycE dimers per asymmetric unit; a novel feature of this crystal, when compared with closely related SycE structures, is a well ordered carboxy-terminal peptide in one protomer of each dimer. The peptide binds a hydrophobic patch of a neighboring molecule in a manner similar to that seen in a SycE-YopE chaperone-target complex, suggestive of low-affinity 'self-binding' through which the carboxy-terminal peptide might suppress counterproductive interactions with non-target proteins in vivo.
<StructureSection load='1n5b' size='340' side='right'caption='[[1n5b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1n5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1md1 1md1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N5B FirstGlance]. <br>
1N5B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_enterocolitica Yersinia enterocolitica]. This structure supersedes the now removed PDB entry 1MD1. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N5B OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n5b OCA], [https://pdbe.org/1n5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n5b RCSB], [https://www.ebi.ac.uk/pdbsum/1n5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n5b ProSAT]</span></td></tr>
==Reference==
</table>
Structure of the Yersinia enterocolitica molecular-chaperone protein SycE., Trame CB, McKay DB, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):389-92. Epub 2003, Jan 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12554962 12554962]
== Function ==
[[Category: Single protein]]
[https://www.uniprot.org/uniprot/YERA_YERE8 YERA_YERE8] Positive regulator of YopE.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n5/1n5b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n5b ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Yersinia enterocolitica]]
[[Category: Yersinia enterocolitica]]
[[Category: McKay, D B.]]
[[Category: McKay DB]]
[[Category: Trame, C B.]]
[[Category: Trame CB]]
[[Category: molecular chaperone]]
[[Category: type iii secretion system]]
[[Category: yersinia enterocolitica]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:02:27 2008''
Retrieved from "https://proteopedia.org/1n5b"