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[[Image:1nw3.png|left|200px]]


{{STRUCTURE_1nw3|  PDB=1nw3  |  SCENE=  }}
==Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase==
 
<StructureSection load='1nw3' size='340' side='right'caption='[[1nw3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
===Structure of the Catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1nw3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NW3 FirstGlance]. <br>
{{ABSTRACT_PUBMED_12628190}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw3 OCA], [https://pdbe.org/1nw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nw3 ProSAT]</span></td></tr>
[[1nw3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NW3 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nw/1nw3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nw3 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Histone methyltransferase|Histone methyltransferase]]
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012628190</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Feng, Q.]]
[[Category: Large Structures]]
[[Category: Li, Z H.]]
[[Category: Feng Q]]
[[Category: Min, J R.]]
[[Category: Li ZH]]
[[Category: Xu, R M.]]
[[Category: Min JR]]
[[Category: Zhang, Y.]]
[[Category: Xu RM]]
[[Category: Hdot1]]
[[Category: Zhang Y]]
[[Category: Histone lysine methyltransferase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/1nw3"