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[[Image:1s48.png|left|200px]]


{{STRUCTURE_1s48|  PDB=1s48  |  SCENE=  }}
==Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV==
 
<StructureSection load='1s48' size='340' side='right'caption='[[1s48]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
===Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1s48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S48 FirstGlance]. <br>
{{ABSTRACT_PUBMED_15070734}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s48 OCA], [https://pdbe.org/1s48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s48 RCSB], [https://www.ebi.ac.uk/pdbsum/1s48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s48 ProSAT]</span></td></tr>
[[1s48]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S48 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/POLG_BVDVN POLG_BVDVN] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (Probable).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>  P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>  Uncleaved NS2-3 is required for production of infectious virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>  NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>  NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>  NS4A is a cofactor for the NS3 protease activity (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>  RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s48_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s48 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[RNA polymerase|RNA polymerase]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:015070734</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Bovine viral diarrhea virus 1]]
[[Category: Bovine viral diarrhea virus 1]]
[[Category: Choi, K H.]]
[[Category: Large Structures]]
[[Category: Groarke, J M.]]
[[Category: Choi KH]]
[[Category: Kuhn, R J.]]
[[Category: Groarke JM]]
[[Category: Pevear, D C.]]
[[Category: Kuhn RJ]]
[[Category: Rossmann, M G.]]
[[Category: Pevear DC]]
[[Category: Smith, J L.]]
[[Category: Rossmann MG]]
[[Category: Young, D C.]]
[[Category: Smith JL]]
[[Category: Bovine viral diarrhea virus]]
[[Category: Young DC]]
[[Category: Bvdv]]
[[Category: De novo initiation]]
[[Category: Polymerase]]
[[Category: Primer independent initiation]]
[[Category: Replication]]
[[Category: Rna binding protein]]
[[Category: Rna virus]]
Retrieved from "https://proteopedia.org/1s48"