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[[Image:3cos.png|left|200px]]


{{STRUCTURE_3cos|  PDB=3cos  |  SCENE=  }}
==Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn==
 
<StructureSection load='3cos' size='340' side='right'caption='[[3cos]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
===Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cos]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3COS FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[3cos]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COS OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cos OCA], [https://pdbe.org/3cos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cos RCSB], [https://www.ebi.ac.uk/pdbsum/3cos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cos ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ADH4_HUMAN ADH4_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/co/3cos_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cos ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Alcohol dehydrogenase|Alcohol dehydrogenase]]
*[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]]
[[Category: Alcohol dehydrogenase]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bishop, S.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bishop S]]
[[Category: Delft, F von.]]
[[Category: Bountra C]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Murray, J.]]
[[Category: Murray J]]
[[Category: Oppermann, U.]]
[[Category: Oppermann U]]
[[Category: Roos, A.]]
[[Category: Roos A]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Shafqat N]]
[[Category: Shafqat, N.]]
[[Category: Yue W]]
[[Category: Yue, W.]]
[[Category: Von Delft F]]
[[Category: Alcohol dehydrogenase]]
[[Category: Medium chain dehydrogenase]]
[[Category: Metal-binding]]
[[Category: Nad]]
[[Category: Oxidoreductase]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Zinc-dependent]]
Retrieved from "https://proteopedia.org/3cos"