3cd7: Difference between revisions

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[[Image:3cd7.png|left|200px]]


{{STRUCTURE_3cd7|  PDB=3cd7  |  SCENE=  }}
==Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors==
 
<StructureSection load='3cd7' size='340' side='right'caption='[[3cd7]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
===Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cd7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CD7 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18540668}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=882:(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC+ACID'>882</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cd7 OCA], [https://pdbe.org/3cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/3cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cd7 ProSAT]</span></td></tr>
[[3cd7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CD7 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cd7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cd7 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[HMG-CoA Reductase|HMG-CoA Reductase]]
*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018540668</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Finzel, B C.]]
[[Category: Large Structures]]
[[Category: Harris, M S.]]
[[Category: Finzel BC]]
[[Category: Pavlovsky, A.]]
[[Category: Harris MS]]
[[Category: Sarver, R W.]]
[[Category: Pavlovsky A]]
[[Category: Cholesterol biosynthesis]]
[[Category: Sarver RW]]
[[Category: Endoplasmic reticulum]]
[[Category: Glycoprotein]]
[[Category: Hmg-coa]]
[[Category: Lipid synthesis]]
[[Category: Membrane]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
[[Category: Statin]]
[[Category: Steroid biosynthesis]]
[[Category: Transmembrane]]
Retrieved from "https://proteopedia.org/3cd7"