2hz6: Difference between revisions

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[[Image:2hz6.png|left|200px]]


{{STRUCTURE_2hz6|  PDB=2hz6  |  SCENE=  }}
==The crystal structure of human IRE1-alpha luminal domain==
 
<StructureSection load='2hz6' size='340' side='right'caption='[[2hz6]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
===The crystal structure of human IRE1-alpha luminal domain===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2hz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HZ6 FirstGlance]. <br>
{{ABSTRACT_PUBMED_16973740}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hz6 OCA], [https://pdbe.org/2hz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2hz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hz6 ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2hz6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZ6 OCA].  
== Function ==
[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hz/2hz6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hz6 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ire1|Ire1]]
*[[Ire1|Ire1]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:016973740</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kaufman, R J.]]
[[Category: Large Structures]]
[[Category: Xu, Z.]]
[[Category: Kaufman RJ]]
[[Category: Zhou, J.]]
[[Category: Xu Z]]
[[Category: Signaling protein]]
[[Category: Zhou J]]
[[Category: Triangular beta-sheet cluster]]
Retrieved from "https://proteopedia.org/2hz6"