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[[Image:2gry.png|left|200px]]


{{STRUCTURE_2gry|  PDB=2gry  |  SCENE=  }}
==Crystal structure of the human KIF2 motor domain in complex with ADP==
 
<StructureSection load='2gry' size='340' side='right'caption='[[2gry]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
===Crystal structure of the human KIF2 motor domain in complex with ADP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2gry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GRY FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
[[2gry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GRY OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gry OCA], [https://pdbe.org/2gry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gry RCSB], [https://www.ebi.ac.uk/pdbsum/2gry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gry ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/KIF2A_HUMAN KIF2A_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/KIF2A_HUMAN KIF2A_HUMAN] Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.<ref>PMID:15843429</ref> <ref>PMID:17538014</ref> <ref>PMID:18411309</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gr/2gry_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gry ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Kinesin|Kinesin]]
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Edwards, A M.]]
[[Category: Bochkarev A]]
[[Category: Landry, R.]]
[[Category: Edwards AM]]
[[Category: Park, H.]]
[[Category: Landry R]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Park H]]
[[Category: Shen, Y.]]
[[Category: Shen Y]]
[[Category: Sundstrom, M.]]
[[Category: Sundstrom M]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Adp]]
[[Category: Kinesin]]
[[Category: Motor domain]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Transport protein]]

Latest revision as of 09:46, 30 August 2023

Crystal structure of the human KIF2 motor domain in complex with ADP

2gry, resolution 2.35Å

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