3c56: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:3c56.png|left|200px]]


{{STRUCTURE_3c56|  PDB=3c56  |  SCENE=  }}
==Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor==
 
<StructureSection load='3c56' size='340' side='right'caption='[[3c56]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Class II fructose-1,6-bisphosphate aldolase from helicobacter pylori in complex with N-(3-Hydroxypropyl)-glycolohydroxamic acid bisphosphate, a competitive inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3c56]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C56 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18688832}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH4:3-{HYDROXY[(PHOSPHONOOXY)ACETYL]AMINO}PROPYL+DIHYDROGEN+PHOSPHATE'>PH4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c56 OCA], [https://pdbe.org/3c56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c56 RCSB], [https://www.ebi.ac.uk/pdbsum/3c56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c56 ProSAT]</span></td></tr>
[[3c56]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C56 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALF_HELPY ALF_HELPY] Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c56_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c56 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[Aldolase 3D structures|Aldolase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018688832</ref><references group="xtra"/>
[[Category: Fructose-bisphosphate aldolase]]
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: M., Coincon.]]
[[Category: Large Structures]]
[[Category: Potvin-Dulude, P.]]
[[Category: Coincon M]]
[[Category: Sygusch,J.]]
[[Category: Potvin-Dulude P]]
[[Category: Aldolase]]
[[Category: Sygusch J]]
[[Category: Class ii]]
[[Category: Fbp]]
[[Category: Glycolysis]]
[[Category: Inhibitor]]
[[Category: Lyase]]
[[Category: Metal-binding]]
Retrieved from "https://proteopedia.org/3c56"