2l3h: Difference between revisions

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[[Image:2l3h.png|left|200px]]


{{STRUCTURE_2l3h|  PDB=2l3h  |  SCENE=  }}
==NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286==
 
<StructureSection load='2l3h' size='340' side='right'caption='[[2l3h]]' scene=''>
===NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2l3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3H FirstGlance]. <br>
{{ABSTRACT_PUBMED_19995078}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3h OCA], [https://pdbe.org/2l3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3h RCSB], [https://www.ebi.ac.uk/pdbsum/2l3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3h ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2l3h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3H OCA].  
== Function ==
[https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>  Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>


==See Also==
==See Also==
*[[Acid phosphatase|Acid phosphatase]]
*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019995078</ref><references group="xtra"/>
__TOC__
[[Category: Acid phosphatase]]
</StructureSection>
[[Category: Brender, J.]]
[[Category: Homo sapiens]]
[[Category: Nanga, R.]]
[[Category: Large Structures]]
[[Category: Popovych, N.]]
[[Category: Brender J]]
[[Category: Ramamoorthy, A.]]
[[Category: Nanga R]]
[[Category: Vivekanandan, S.]]
[[Category: Popovych N]]
[[Category: Hydrolase]]
[[Category: Ramamoorthy A]]
[[Category: Pap248-286]]
[[Category: Vivekanandan S]]
[[Category: Sevi]]
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