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[[Image:2dxe.png|left|200px]]


{{STRUCTURE_2dxe|  PDB=2dxe  |  SCENE=  }}
==Crystal structure of nucleoside diphosphate kinase in complex with GDP==
 
<StructureSection load='2dxe' size='340' side='right'caption='[[2dxe]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
===Crystal structure of nucleoside diphosphate kinase in complex with GDP===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2dxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DXE FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[2dxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXE OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dxe OCA], [https://pdbe.org/2dxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dxe RCSB], [https://www.ebi.ac.uk/pdbsum/2dxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dxe ProSAT], [https://www.topsan.org/Proteins/RSGI/2dxe TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NDK_PYRHO NDK_PYRHO] Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dxe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dxe ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nucleoside diphosphate kinase|Nucleoside diphosphate kinase]]
*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
[[Category: Nucleoside-diphosphate kinase]]
__TOC__
[[Category: Pyrococcus horikoshii]]
</StructureSection>
[[Category: Kato-Murayama, M.]]
[[Category: Large Structures]]
[[Category: Murayama, K.]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Kato-Murayama M]]
[[Category: Shirouzu, M.]]
[[Category: Murayama K]]
[[Category: Terada, T.]]
[[Category: Shirouzu M]]
[[Category: Yokoyama, S.]]
[[Category: Terada T]]
[[Category: Kinase]]
[[Category: Yokoyama S]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Nucleoside binding]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Structural genomic]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2dxe"