1smc: Difference between revisions
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==Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.== | |||
<StructureSection load='1smc' size='340' side='right'caption='[[1smc]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1smc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DUT:DEOXYURIDINE-5-TRIPHOSPHATE'>DUT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smc OCA], [https://pdbe.org/1smc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smc RCSB], [https://www.ebi.ac.uk/pdbsum/1smc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smc ProSAT]</span></td></tr> | ||
[[1smc]] is a 3 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1smc_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1smc ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[ | *[[DUTPase 3D structures|DUTPase 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Large Structures]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Cascio D]] | |||
[[Category: Cascio | [[Category: Chan S]] | ||
[[Category: Chan | [[Category: Cho US]] | ||
[[Category: Cho | [[Category: Eisenberg D]] | ||
[[Category: Eisenberg | [[Category: Kim C-Y]] | ||
[[Category: Kim | [[Category: Kim M-Y]] | ||
[[Category: Kim | [[Category: Krupka H]] | ||
[[Category: Krupka | [[Category: Lekin T]] | ||
[[Category: Lekin | [[Category: Naranjo CM]] | ||
[[Category: Naranjo | [[Category: Park MS]] | ||
[[Category: Park | [[Category: Pashkov I]] | ||
[[Category: Pashkov | [[Category: Perry JL]] | ||
[[Category: Perry | [[Category: Rogers YC]] | ||
[[Category: Rogers | [[Category: Sawaya MR]] | ||
[[Category: Sawaya | [[Category: Segelke B]] | ||
[[Category: Segelke | [[Category: So M]] | ||
[[Category: So | [[Category: Terwilliger TC]] | ||
[[Category: Waldo GS]] | |||
[[Category: Terwilliger | [[Category: Yeates TO]] | ||
[[Category: Waldo | |||
[[Category: Yeates | |||
Latest revision as of 08:32, 14 February 2024
Mycobacterium tuberculosis dUTPase complexed with dUTP in the absence of metal ion.
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