1bai: Difference between revisions

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[[Image:1bai.png|left|200px]]


{{STRUCTURE_1bai|  PDB=1bai  |  SCENE=  }}
==Crystal structure of Rous sarcoma virus protease in complex with inhibitor==
 
<StructureSection load='1bai' size='340' side='right'caption='[[1bai]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Crystal structure of Rous sarcoma virus protease in complex with inhibitor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1bai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAI FirstGlance]. <br>
{{ABSTRACT_PUBMED_9521772}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q4:N-[(2R)-2-({N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHYL-L-VALYL}AMINO)-4-METHYLPENTYL]-L-PHENYLALANYL-L-ALPHA-GLUTAMYL-L-ALANYL-L-NORLEUCINAMIDE'>0Q4</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bai OCA], [https://pdbe.org/1bai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bai RCSB], [https://www.ebi.ac.uk/pdbsum/1bai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bai ProSAT]</span></td></tr>
[[1bai]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus Rous sarcoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAI OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/1bai_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bai ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Virus protease|Virus protease]]
*[[Virus protease 3D structures|Virus protease 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009521772</ref><ref group="xtra">PMID:017352531</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Rous sarcoma virus]]
[[Category: Rous sarcoma virus]]
[[Category: Adomat, J M.]]
[[Category: Adomat JM]]
[[Category: Harrison, R W.]]
[[Category: Harrison RW]]
[[Category: Leis, J.]]
[[Category: Leis J]]
[[Category: Louis, J M.]]
[[Category: Louis JM]]
[[Category: Ridky, T W.]]
[[Category: Ridky TW]]
[[Category: Weber, I T.]]
[[Category: Weber IT]]
[[Category: Wu, J.]]
[[Category: Wu J]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Protein-mediated interaction]]
[[Category: Viral maturation]]
Retrieved from "https://proteopedia.org/1bai"