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[[Image:1m4c.png|left|200px]]


{{STRUCTURE_1m4c|  PDB=1m4c  |  SCENE=  }}
==Crystal Structure of Human Interleukin-2==
 
<StructureSection load='1m4c' size='340' side='right'caption='[[1m4c]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Crystal Structure of Human Interleukin-2===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1m4c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M4C FirstGlance]. <br>
{{ABSTRACT_PUBMED_12582206}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4c OCA], [https://pdbe.org/1m4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m4c RCSB], [https://www.ebi.ac.uk/pdbsum/1m4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m4c ProSAT]</span></td></tr>
==About this Structure==
</table>
[[1m4c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M4C OCA].  
== Disease ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
== Function ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/1m4c_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m4c ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Interleukin|Interleukin]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:012582206</ref><ref group="xtra">PMID:012767230</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arkin, M A.]]
[[Category: Large Structures]]
[[Category: Braisted, A C.]]
[[Category: Arkin MA]]
[[Category: DeLano, W L.]]
[[Category: Braisted AC]]
[[Category: Hyde, J.]]
[[Category: DeLano WL]]
[[Category: Luong, T N.]]
[[Category: Hyde J]]
[[Category: McDowell, R S.]]
[[Category: Luong TN]]
[[Category: Oslob, J D.]]
[[Category: McDowell RS]]
[[Category: Randal, M.]]
[[Category: Oslob JD]]
[[Category: Raphael, D R.]]
[[Category: Randal M]]
[[Category: Taylor, L.]]
[[Category: Raphael DR]]
[[Category: Wang, J.]]
[[Category: Taylor L]]
[[Category: Wells, J A.]]
[[Category: Wang J]]
[[Category: Cytokine]]
[[Category: Wells JA]]
[[Category: Four-helix bundle]]
Retrieved from "https://proteopedia.org/1m4c"