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[[Image:3cfo.png|left|200px]]


{{STRUCTURE_3cfo|  PDB=3cfo  |  SCENE=  }}
==Triple Mutant APO structure==
 
<StructureSection load='3cfo' size='340' side='right'caption='[[3cfo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
===Triple Mutant APO structure===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_RB69 Escherichia phage RB69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFO FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[3cfo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_rb69 Enterobacteria phage rb69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFO OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfo OCA], [https://pdbe.org/3cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfo RCSB], [https://www.ebi.ac.uk/pdbsum/3cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfo ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
[[Category: DNA-directed DNA polymerase]]
__TOC__
[[Category: Enterobacteria phage rb69]]
</StructureSection>
[[Category: Klimenko, D.]]
[[Category: Escherichia phage RB69]]
[[Category: Konigsberg, W H.]]
[[Category: Large Structures]]
[[Category: Steitz, T A.]]
[[Category: Klimenko D]]
[[Category: Wang, J.]]
[[Category: Konigsberg WH]]
[[Category: Wang, M.]]
[[Category: Steitz TA]]
[[Category: Apo]]
[[Category: Wang J]]
[[Category: Base selectivity]]
[[Category: Wang M]]
[[Category: Closed]]
[[Category: Dna replication]]
[[Category: Dna-binding]]
[[Category: Dna-directed dna polymerase]]
[[Category: Exonuclease]]
[[Category: Half-closed]]
[[Category: Hydrolase]]
[[Category: Nuclease]]
[[Category: Nucleotidyltransferase]]
[[Category: Open]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3cfo"