1m5v: Difference between revisions

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[[Image:1m5v.png|left|200px]]


{{STRUCTURE_1m5v|  PDB=1m5v  |  SCENE=  }}
==Transition State Stabilization by a Catalytic RNA==
 
<StructureSection load='1m5v' size='340' side='right'caption='[[1m5v]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
===Transition State Stabilization by a Catalytic RNA===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[1m5v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M5V FirstGlance]. <br>
{{ABSTRACT_PUBMED_12376595}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m5v OCA], [https://pdbe.org/1m5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m5v RCSB], [https://www.ebi.ac.uk/pdbsum/1m5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m5v ProSAT]</span></td></tr>
[[1m5v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M5V OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m5/1m5v_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m5v ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Nucleoprotein|Nucleoprotein]]
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
*[[Ribozyme|Ribozyme]]
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:012376595</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Amare, A R.Ferre-D.]]
[[Category: Large Structures]]
[[Category: Massey, A P.]]
[[Category: Ferre-D'Amare AR]]
[[Category: Rupert, P B.]]
[[Category: Massey AP]]
[[Category: Sigurdsson, S T.]]
[[Category: Rupert PB]]
[[Category: Catalytic rna]]
[[Category: Sigurdsson ST]]
[[Category: Cleaved substrate]]
[[Category: Hairpin ribozyme]]
[[Category: Translation-rna complex]]
[[Category: U1a rna binding protein 2'3'cyclic phosphate]]
Retrieved from "https://proteopedia.org/1m5v"