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[[Image:3cmm.png|left|200px]]


{{STRUCTURE_3cmm|  PDB=3cmm  |  SCENE=  }}
==Crystal Structure of the Uba1-Ubiquitin Complex==
 
<StructureSection load='3cmm' size='340' side='right'caption='[[3cmm]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
===Crystal Structure of the Uba1-Ubiquitin Complex===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3cmm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CMM FirstGlance]. <br>
{{ABSTRACT_PUBMED_18662542}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cmm OCA], [https://pdbe.org/3cmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cmm RCSB], [https://www.ebi.ac.uk/pdbsum/3cmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cmm ProSAT]</span></td></tr>
[[3cmm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CMM OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBA1_YEAST UBA1_YEAST] Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/3cmm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cmm ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Ubiquitin|Ubiquitin]]
*[[3D structures of Ubiquitin activating enzyme|3D structures of Ubiquitin activating enzyme]]
 
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
==Reference==
__TOC__
<ref group="xtra">PMID:018662542</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Lee I]]
[[Category: Lee, I.]]
[[Category: Schindelin H]]
[[Category: Schindelin, H.]]
[[Category: Adenylation]]
[[Category: Atp-binding]]
[[Category: Conformational change]]
[[Category: Dna damage]]
[[Category: Dna repair]]
[[Category: E1]]
[[Category: Ligase]]
[[Category: Ligase-protein binding complex]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Protein turnover]]
[[Category: Thioester]]
[[Category: Transthioesterification]]
[[Category: Uba1]]
[[Category: Ubiquitin]]
[[Category: Ubl conjugation pathway]]
Retrieved from "https://proteopedia.org/3cmm"